The EU-TOPIA team has worked very hard to build natural history models (MISCAN) of the three cancer sites for all 4 regions in Europe. Based on the MISCAN models, the EU-TOPIA evaluation tool was designed to allow users to simulate outcomes, benefits and harms of several cancer screening strategies for their own country. The participants of the 2nd EU-TOPIA workshop will be the first to be introduced to use and test this tool. We are very excited!