The work package on model development (WP4) is coordinated by Iris Lansdorp-Vogelaar, PhD. She is Assistant Professor of Screening Evaluation and responsible for the section of early detection of colorectal and esophageal cancer of the Department of Public Health. She has been responsible for the management and development of the MISCAN-Colon model since 2003, and the UW-MISCAN esophagus model since its initiation in 2010. Her modelling work informed the 2008 US Preventive Services Task Force recommendations, US Medicare reimbursement decisions on computed tomographic colonograpy (CTC) and Stool DNA screening and the Dutch national colorectal cancer screening program. She is a member of the European Cancer Network and lead author of a chapter in the European Guidelines for Quality Assurance in Colorectal Cancer Screening. Her current research further focuses on explaining colorectal cancer disparities, on individualizing colorectal cancer screening and surveillance recommendations.